VPT 421: Veterinary Toxicology (2+0)

AMITRAZ

• Amitraz is used as a topical miticide.
• It is used as a topical solution or as a collar to control fleas.
• In dogs, dermal absorption following dipping is a common route of exposure resulting in toxicosis.
• Ingestion by dogs of amitraz -containing collars is becoming more common as their use becomes more widespread.
• Puppies up to 3 - 4 months old seem to be especially sensitive to amitraz .
• Amitraz is not approved for use in cats. Toxicosis has been reported in cats following administration of the liquid preparation in the external ear canal.
• It is an α2 adrenergic agonist and weak mono amine oxidase inhibitor.
• Causes cardiovascular collapse and respiratory depression.
• Bradycardia, ataxia, depression, disorientation, vomiting, anorexia, polyuria, diarrhea, vocalization and seizures are the symptoms observed.
• In poisoning treatment is symptomatic. Yohimbine can reverse the toxic effects.