VPT 421: Veterinary Toxicology (2+0)

TOXICOKINETICS

• Pyrethroids are lipophilic and are absorbed rapidly after entry through oral, dermal or inhalation routes.
• Rapid hydrolysis of ester linkage in digestive tract results in low oral toxicity.
• Most are rapidly metabolized by ester hydrolysis and via oxidation by liver microsomal enzymes.
• The resulting alcohol, phenol, or carboxylic acid metabolites are often conjugated with glycine, glucuronide, sulfate and glucoside prior to excretion through kidneys.