Principles of Biochemistry

7.5.1.4 Termination

The polypeptide continues to grow by way of translocation until all necessary amino acids are in place and bonded to each other.

Appearance in the mRNA codon sequence of one of the three stop codons(UAA,UAG, or UGA) terminates the process. No tRNA has an anticodon that can base-pair with these stop codons. The polypeptide is then cleaved from the tRNA through hydrolysis.