Difference between competitive and non competitive neuromuscular blocker

DIFFERENCE BETWEEN COMPETITIVE AND NON-COMPETITIVE BLOCKERS


Competitive blocker (d-tubocurarine)

Depolarizing blocker (Succinylcholine)

Paralysis in human

Flaccid

Fasiculation resulting in flaccidity

Paralysis in chick

Flaccid

Spastic

Species sensitivity

Rat>Rabbit>Cat

Cat>Rabbit>Rat

Neostigmine

Antagonism block

No effect

Inhalation anaesthetic (ether)

Synergistic

No effect

Order of paralysis

Fingers-eyes-limbs-neck-face-trunk-intercostal muscles

Neck-limbs-face-jaw-eyes-pharynx-trunk-intercostal muscles


Last modified: Wednesday, 16 May 2012, 5:44 AM