VPT 321: Veterinary Neuropharmacology (2+1) copy 1

INTERACTIONS

• Thiopentone  and Succinylcholine-react chemically. Hence donot mix in same syringe.
• General anaesthetics potentiates competitive blockers.
• Isoflurane potentiates more than halothane
• ketamine intensifies nondepolarizing blockers.
• Adrenaline and other sympathomimetics reduce competitive blocker by increasing Ach release.
• Diuretics produce hypokalaemia -enchancing competitive block.
• Calcium channel blockers verapamil potentiate both type of blockers.
• Anticholinesterases reverse the action of competitive blockers.
• Muscarinic action of neostigmine can be prevented by atropinization. Pretreatment with antihistamines is indicated.
• Aminoglycosides reduces Ach release from prejunctional nerve ending by competing with calcium ions. So the dose of competitive blockers should be reduced in patients receiving high doses of antibiotics.