VPT 321: Veterinary Neuropharmacology (2+1) copy 1

USES AND TOXICITY

Uses

• As an adjunct to general anaesthesia.
• Succinylcholine is employed for brief procedures.
• Convulsions and trauma from electroconvulsive therapy can be avoided by use of muscle relaxants. Succinylcholine can be used for this purpose.
• In severe cases of tetanus and status epilepticus not controlled by benzodiazepines. 

Toxicity

• Respiratory paralysis and prolonged apnoea
• Flushing common with d-tubocurarine
• Fall in blood pressure and cardiovascular collapse can occur in hypovolaemic conditions
• In digitalized individuals cardiac arrhythmias and even arrest can occur with succinylcholine.
• Precepitation of asthma with d-tubocurarine
• Post operative muscle sorenes with succinylcholine