Toxicokinetics

TOXICOKINETICS

  • Absorption of warfarin is rather complete but occurs slowly.
  • Most of the warfarin is bound to plasma protein, but high concentrations are also found in the liver, spleen and kidney.
  • Plasma proteins (albumin) play a significant role in the patient's response to an anticoagulant.
  • Warfarin is over 90% bound in canine plasma which acts as a reservoir.
  • Inactive hydroxylated metabolites have been found in the urine.
  • The anticoagulant rodenticides are eliminated at various rates, depending on the compound and the amount ingested.
Last modified: Sunday, 20 November 2011, 10:25 AM