3.6.1.2 Conversion of citrate to isocirtrate via cis-aconitate

3.6.1.2 Step 2: Conversion of Citrate to Isocitrate via Cis-Aconitate

Citrate is converted to isocitrate by the enzyme aconitase which contains iron in the Fe2+ state in the form of an iron- sulfur protein (Fe:S). This conversion takes place in two steps: dehydration to cis-aconitate, some of which remains bound to the enzyme, and rehydration to iocitrate.

Aconitase Aconitase

Citrate cis-aconitate isocitrate
Last modified: Thursday, 10 November 2011, 9:56 AM