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3.6.1.3 Dehydrogenation of isocitrate to oxalosuccinate
Isocitrate undergoes dehydrogenation in the presence of isocitrate dehydrogenase to form oxalosuccinate.The linked oxidation of isocitrate proceeds almost completely through the NAD+ dependent enzyme isocitrate dehydrogenase. There follows decarboxylation of oxalosuccinate to α-ketoglutarate, also catalyzed by isocitrate dehydrogenase. A CO2 molecule is liberated. Mn2+(or Mg2+) is an important component of the decarboxylation . Isocitrate dehydrogenase Oxalosuccinate ↔α-ketoglutarate + CO2 |
Last modified: Thursday, 10 November 2011, 9:57 AM