Site pages
Current course
Participants
General
18 February - 24 February
25 February - 3 March
4 March - 10 March
11 March - 17 March
18 March - 24 March
25 March - 31 March
1 April - 7 April
8 April - 14 April
15 April - 21 April
22 April - 28 April
6.5.2.3. Cleavage by thiolase
Finally, 3-ketoacyl-CoA is spilt at the 2, 3- position by thiolase (3-ketoacyl-CoA-thiolase), which catalyzes a thiolytic cleavage involving another molecule of CoA.
The products of this reaction are acetyl-CoA and an acyl-CoA derivative containing two carbons less than the original acyl-CoA molecule that underwent oxidation. The acyl-CoA formed in the cleavage reaction renters the oxidative pathway at reaction 2.
In this way, a long-chain fatty acid may be degraded completely to acetyl-CoA (C2 units). Since acetyl-CoA can be oxidized to CO2 and water via the citric acid cycle (which is also found within the mitochondria), the complete oxidation of fatty acids in achieved. |
Last modified: Saturday, 12 November 2011, 5:44 AM