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6.5.3 Production of ATP
Transport of hydrogen atoms and electron from FADH2 and NADH in the respiratory chain will lead to the synthesis of five high energy phosphates for each of the first seven acetyl-CoA molecules formed by- ß- oxidation of palmitate 5x7= 35 by 5 cycles A total of 8 mol of acetyl-CoA is formed by the complete oxidation of a palmitic acid with 16 carbon atoms. Each acetyl-CoA will give rise to 12 ATP on oxidation in the citric acid cycle, 8 x 12 =96ATP Two ATP molecules that are used for the initial activation of the fatty acid must be subtracted, yielding a net gain of 129 mol of ATP per mole of oxidation./font>/font>
Molecules of ATP formed 1. Palmitate to palmitylCoA : -2 2. Palmityl CoA to 8 Acetyl CoA a) 7FADH2 to 7FAD (7x3=14) : 14 b) 7NADH+H+ to 7NAD+ (7x3=21) : 21 3. 8 AcetylCoA to 16CO2+8H2O+8CoASH ; 96 ------ Net production 129 ----- |