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6.5.2.3. Cleavage by thiolase
Finally, 3-ketoacyl-CoA is spilt at the 2, 3- position by thiolase (3-ketoacyl-CoA-thiolase), which catalyzes a thiolytic cleavage involving another molecule of CoA.
The products of this reaction are acetyl-CoA and an acyl-CoA derivative containing two carbons less than the original acyl-CoA molecule that underwent oxidation. The acyl-CoA formed in the cleavage reaction renters the oxidative pathway at reaction 2.
In this way, a long-chain fatty acid may be degraded completely to acetyl-CoA (C2 units). Since acetyl-CoA can be oxidized to CO2 and water via the citric acid cycle (which is also found within the mitochondria), the complete oxidation of fatty acids in achieved. |
Last modified: Saturday, 12 November 2011, 5:44 AM