Mechanism of Toxicity

MECHANISM OF TOXICITY

  • Excessive fluoride results in delayed and impaired mineralization of teeth and skeleton.
  • In the teeth, fluoride damages the ameloblasts and odontoblasts. This leads to abnormalities on developing teeth.
  • In fully developed teeth, enamel formation does not occur and this leads to rapid and excessive wear of molars and incisors.
  • Oxidation of organic material in the areas of wear results in brown or black discolouration.
  • In the bones fluorides disrupt osteogenesis, causes acceleration of bone remodelling with production of abnormal bones.
  • Occasionally osteoporosis may also be caused.
Last modified: Monday, 22 August 2011, 2:43 PM