Biotechnology and Bioinformatics (1+1)

4.3.10. Gene tic vaccines or Nucleic acid vaccines

Genetic vaccines consist only of DNA (as plasmid s) or RNA (as mRNA), which is taken up by cells and translated into protein . In case of gene-gun delivery, plasmid DNA is precipitated on to an inert particle (generally gold beads) and forced into the cells with a helium blast. Transfected cells then express the antigen encoded on the plasmid resulting in an immune response.