Biotechnology and Bioinformatics (1+1)

4.3.2. Mode of preparation of fish vaccines

The bacterial fish vaccines may be categorized as follows.

i) Chemically or heat inactivated whole cells. These vaccines may be mono or polyvalent.

ii) Inactivated soluble cell extracts. i.e. Toxoids.

iii) Cell lysate

iv) Attenuated live vaccines, possibly gene tically engineered cells. There is a perceived risk that the vaccine strain may revert to pathogenic mode.

v) Purified sub-cellular components, e.g. LPS. These vaccines require a detailed understanding of microbial biochemistry.